Antimicrobial Susceptibility

CDC launches the Antibiotic Resistance Laboratory Network – learn how you can help combat AR
Microbiologists working in clinical and hospital labs understand the increasing prevalence of antimicrobial resistance (AR) and its devastating effect on treatment options and patient health. In fall 2016, CDC launched the Antibiotic Resistance Laboratory Network (AR Lab Network, or ARLN) to better detect and respond to resistant organisms, and you can participate.

Key Points

  • The ARLN boosts state and local testing capacity and technology to detect, support response to, and prevent AR threats across the nation.
  • This capacity will inform prevention efforts to reduce transmission of resistant pathogens, ultimately saving lives.
  • CDC needs your help! Clinical microbiologists on the front lines can help combat AR and participate in the network by submitting isolates from your hospital and clinical laboratories.
  • Work is ongoing to ensure hospitals can implement this testing capacity and access the data. Shipping of isolates and specimens is free to hospital labs and new web-based tools for reporting are in progress.
  • Join the webinar cohosted by ASM and APHL on Feb. 14th, 2PM, to learn more about ARLN and how to submit isolates.

About the AR Lab Network
ARLab LogoFINAL rgb no taglineThe recently launched CDC AR Lab Network includes seven regional labs that will support a network of public health labs, hospitals, and clinical labs with increased capacity for specialized testing and rapid response to 7+ antibiotic-resistant pathogens identified by CDC as urgent or serious threats. Pathogens screened by the AR Lab Network include CRE, gonorrhea, and Salmonella.

When new resistance threats or outbreaks are detected within healthcare facilities or state/local labs, the seven state health department labs designated as regional labs will work together with CDC and state/local health department labs to provide support, where needed, to characterize, support response, and track these discoveries.

This network was formed in response to national objectives to strengthen surveillance efforts by creating a regional public health laboratory network to detect resistant bacterial strains. Visit CDC's antibiotic resistance website for more information on the regional labs and how ARLN will work.

ARLN Fast Facts

Learn More about ARLN & How to Submit Isolates: Join the Webinar & Share with Colleagues
You may have received information from your public health laboratory regarding the types of testing and sample types needed to support this testing initiative. To share additional information, ASM, with CDC and APHL, is hosting a webinar on Feb. 14 to describe ARLN to clinical microbiologists. The webinar will cover how you can participate and submit isolates from your hospital or clinical lab, and will give time for you to share feedback and ask questions. Click here to register for the webinar.

These new efforts will benefit the laboratory, facility, and patients, and ultimately save lives. Your participation in the ARLN and work to generate the latest AR lab data can help drive that response and prevention. We look forward to working with you on this initiative.

If you have questions, please contact your local/state public health laboratory or email CDC at This email address is being protected from spambots. You need JavaScript enabled to view it. .



Phenotypic Detection of β-Lactamase Resistance in Gram-Negative Bacilli: Testing and Interpretation Guide
To detect isolates with AmpC, K1, and KPC enzymes, as well as those with ESBLs, it is desirable to test all Enterobacteriaceae with a combination of antibiotics that will allow detection of resistant mechanisms. In Dr. Paul Schreckenberger's laboratory, he and Violeta Rekasius, MT(ASCP) have expanded the ESBL confirmatory disk test to include 12 antibiotic disks and have applied the test to all members of the Enterobacteriaceae that have a susceptibility pattern that is suspicious for the presence of an ESBL, AmpC, K1 or KPC type resistance gene. Through the application of this test they have been able to successfully detect antibiotic resistance in many species of Enterobacteriaceae that would have not been detected using their automated susceptibility testing system.